QSB: Dynamic Contraints Based Modeling of the Escherichia coli Metabolic Network

University Of Delaware, Newark DE

Investigators

Abstract

The overall goal is to develop quantitative descriptions of bacterial metabolism to help elucidate the genotype-phenotype relation. The focus is on augmenting network analysis and phenotype prediction by accounting for genetic-level capabilities and control mechanisms. The tasks are to perform a sensitivity analysis of a simplified E. coli network model contained using Lagrange multipliers from nonlinear programming and to collect data on constraints for a large scale dynamic FBA simulation from the literature and existing online databases. The union of biochemical engineering and system analysis investigators will provide significant cross-training to the student involved.