HIGH RESOLUTION DATA ON CDK2 CKS HS1 COMPLEX

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

Cks proteins belong to the new family of domain swapping proteins, that include several other interwined and dimeric protein structures in which the new assembly is essential for their function. Gel filtration experiments performed with these Cks molecules in presence of the CDK2 kinase clearly reinforces this hypothesis. We wish to determine with SR, the first structure between the CDK2 kinase and one of its important partner during cell cycle progression, CksHs1.

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