STRUCTURE BASED DRUG DESIGN W/ HIV INTEGRASE

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

We wish to collect data to determine the X-ray structure of the complex of the HNF-1a dimerization domain and DcoH. This would allow us to define interactions that mediate recognition and characterize any conformational changes that may help stimulate gene expression.

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