DNA DAMAGE REPAIR ENZYMES;ENDONUCLEASE IV &MANGANESE SUPEROXIDE DISMUTASE

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

Investigators

Linked publications & trials

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Abstract

EndoIV is a DNA repair enzyme. Its activity is to catalyze the cleavage of DNA at apurinic sites. Recent reports show that nitric oxide and superoxide trigger endoIV expression suggesting that endoIV is important for survival of pathogens. We would like to solve the structure of endoIV to explain the mechanism of this enzyme.

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