CRYSTALLOGRAPHIC STUDIES OF RECEPTORS &OF PROTEIN &DNA INTERACTIONS: HIV-RT

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

Investigators

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Abstract

We wish to look at DNA and drug adducts in the yeast topoisomerase II structure which we recently determined using data from SSRL. The unliganded HIV-RT crystals we have studied are likewise suitable for soaking DNA fragments and other ligands. We are also attempting to prepare certain co-crystals with synthetic template/primer. We propose to collect heavy-atom derivative data at SSRL. Our crystals of TFIIIA in complex with a 31 bp DNA fragment are "ready" for the synchrotron.

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