CRYSTALLOGRAPHIC INVESTIGATION OF G COUPLED SIGNAL CASCADE

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

Signaling cascades provide mechanisms to receive, transmit and amplify cellular messages, and thus are critical pathways for mounting a cellular response to an extra-cellular stimulus. The opportunity to understand the structure and function of a G protein signal transduction cascade at the atomic level is the underlying goal of this proposal.

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