DATA COLLECT: HEAVY ATOM DERIVATIVES OF EPSTEIN BARR VIRUS NUCLEAR ANTIGEN 1

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

The Epstein Barr Virus Nuclear Antigen-1 (EBNA1) orchestrates the initiation of DNA replication from the latent origin of this virus. EBNA1 belongs to a class of proteins that have not been probed by high resolution structural techniques. We have high quality crystals that are amenable to X-ray diffraction studies. The solution to this structure will allow for a molecular understanding of the events leading up to cell division in eukaryotes.

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