STRUCTURE OF BPI HUMAN BACTERICIDAL &PERMEABILITY INCREASING PROTEIN

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

Bactericidal/permeability-increasing protein (BPI) from human polymorphonuclear neutrophils plays a major role in the host defensive response to gram-negative infections. This 50 kD cationic protein binds to the lipid A region of lipopolysaccharide (LPS) with high affinity, neutralizes the biological activities of LPS, and has potent bactericidal activity against a wide range of gram-negative bacteria. Because of these properties, BPI is under investigation as a novel clinical treatment for septic shock. Screening of more potential derivatives for multiple isomorphous replacement is currently in progress. Native data has been collected and appears to extend to 2.5 E resolution and is currently 40% complete.

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