XRAY CRYSTALLOGRAPHIC STUDIES OF MURZ ENZYME

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

Investigators

Linked publications & trials

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Abstract

The involvement of MurZ in bacterial cell wall biosynthesis makes the enzyme a potential target for the development of new antibacterial agents and indeed, MurZ is the site of action of the antibiotic fosfomycin. The three dimensional structure of MurZ will be very helpful for understanding the mechanism of this enzyme and designing new antibacterial drugs.

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