ANALYSIS OF KINESIN MOTOR DOMAIN

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

Kinesin is the premier member of the family of microtubule-associated force-producing proteins which use ATP hydrolysis for power generation. We have crystallized the motor domain of the human kinesin heavy chain in order to obtain an X-ray structure of this region. Since there currently exists no high resolution structure for a kinesin-like protein, a structure of this domain would set the stage for an in depth exploration of ATP hydrolysis-driven protein motor activity.

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