USING MAD FOR AN HSF DNA COMPLEX

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

We are using multiple anomalous dispersion (MAD) to determine the structure of a complex between the DNA binding domain of the heat shock transcription factor (HSF) along with a 10-mer of DNA containing its cognate binding site. Data was collected on crystals containing selenomethionine-substituted protein. The electron density maps show that the protein is well ordered, but the DNA is not.

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