DIFFRACTION OF GDP DISSOCIATION INHIBITOR (GDI) FROM DROSOPHILA MELANOGSTER

$143,176P41FY2002RRNIH

Stanford University, Stanford CA

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Abstract

GDP dissociation inhibitor (GDI) is a regulator of small ras-like GTPases of the rab subfamily. The rab GTPases control steps in vesicular transport, involving both secretion and endocytosis. Moreover, in the cell-division mutant of Drosophila, quartet, rab GDI is shifted in isoelectric point, suggesting that GDI may play a role in governing the onset and progression of cell division.

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