STRUCTURAL DEFECTS CAUSED BY TUMOR DERIVED MUTATIONS IN TUMOR SUPPRESSOR P16

$157,506P41FY2002RRNIH

Washington University, Saint Louis MO

Investigators

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Abstract

The goal of this study is to understand how tumor-derived mutations disrupt the structure and function of tumor suppressor p16INK4a and to investigate the possibility of restoring the the function of mutant p16 proteins by stabilization of the native state.

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