TOTAL SYNTHESIS OF INDOLE ALKALOIDS: ANTI HIV COMPOUNDS

$157,506P41FY2002RRNIH

Washington University, Saint Louis MO

Investigators

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Abstract

This work is focussed on the synthesis of vinblastine type alkaloids for anti-cancer testing, and 18-methoxycoronaridine and congeners for anti-addictive and for HIV-Lychmania inhibition. Syntheses are typically 12 to 25 steps land and require MS characterization of intermediates and products.

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