Purchase of an Electrospray LC-Quadrupole Ion Trap Mass Spectrometer

Brown University, Providence RI

Investigators

Abstract

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Brown University will acquire an Electrospray LC-Quadrupole Ion Trap Mass Spectrometer. This equipment will enhance research in a number of areas including a) the biosynthesis of polyketide and other natural products; b) screening of the activity of a combinatorial library of peptide-based protease inhibitors; c) analysis of complex glycolipids involved in molecular recognition events on cell surfaces; d) investigations of enolate structures; e) analysis of recombinantly expressed proteins used to study biochemical recognition processes; and f) investigations of the structure of adducts that play a role in carcinogenicity. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The results from these studies will have an impact in a number of areas including medicinal chemistry and biology.