Defining renal S1P/sPRR/AT1R pathway in salt-sensitive hypertension

Va Salt Lake City Healthcare System, Salt Lake City UT

Investigators

Linked publications & trials

Abstract

The important role of renin-angiotensin-aldosterone system in the pathogenesis of hypertension is highlighted by the wide use of its inhibitors for treatment of hypertension. The current proposal will address the role of renal site-1 protease/soluble (pro)renin receptor in pathogenesis of salt-sensitive hypertension. The proposal has the potential to advance our understanding of the fundamental mechanism of hypertension and also to identify a novel target for antihypertensive therapies.