Structural and Functional Studies of the Uterine Lymphatics

Beth Israel Deaconess Medical Center, Boston MA

Investigators

Linked publications, trials & patents

Abstract

PROGRAM SUMMARY The uterus is a highly-fluid dynamic organ that experiences significant structural and physiological changes throughout the estrus cycles, embryo implantation, pregnancy, and post-delivery. These phases are characterized by rapid fluctuations in tissue fluid content and extensive vascular remodeling, which are optimally designed for successful reproduction. Uterine lymphatics are thought to play key roles in managing uterine tissue fluid homeostasis and regulating immune tolerance towards the fetus during pregnancy. Despite their crucial roles in maintaining fluid balance and facilitating immune responses, the current understanding of the development, structure, and function of the uterine lymphatics remains limited, especially when compared to the well-studied uterine blood vessels. This project aims to gain a better understanding of the structure and function of the uterine lymphatics, focusing on their growth and patterning, anatomical organization, remodeling, and functional significance during pregnancy and non-pregnant states. Our research will not only shed light on the development and function of the uterine lymphatics, but also offer wider perspectives on common uterine health and disease challenges.