Antibody Neutralization Mechanisms

$1,366,331ZIAFY2025AINIH

National Institute Of Allergy And Infectious Diseases

Investigators

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Abstract

Highly effective neutralizing antibodies could have utility in the prevention or treatment of infection from HIV-1, norovirus, influenza virus, and other human pathogens. Much of our work on neutralizing antibodies has focused on identifying, characterizing and in many cases improving naturally elicited antibodies. Improved HIV-1 neutralizing antibodies include versions of CD4-binding site-directed antibodies capable of neutralizing over 95% of HIV strains and fusion-peptide-directed antibodies that neutralize over 60% of HIV strains. Some of these have been manufactured and assessed clinically. We are also working in collaboration with other groups to identify and to characterize effective neutralizing antibodies against other human pathogens. Overall, our antibody-related work involves understanding antibodies for vaccine insights and improving antibodies as possible therapeutic agents against wide variety of human pathogens.

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