Myeloid TGFbeta signaling in breast cancer metastasis and dormancy

Division Of Basic Sciences - Nci

Investigators

Linked publications, trials & patents

Abstract

we discovered a significant impact of myeloid TGFbeta on tumor immune evasion and metastatic outgrowth. Currently, we are investigating the underlying cellular and molecular mechanisms. We are utilizing the knockout mouse line of myeloid specific TGFbeta signaling to understand immune therapy resistance/relapse, a significant challenge in cancer biology and treatment. We have preliminary observations on immune niches that governs tumor dormancy and metastatic outgrowth, which should inform novel targeting opportunities