Identifying small molecules with selective toxicity towards muscle invasive prostate cancer cells

National Center For Advancing Translational Sciences

Investigators

Abstract

This project team aims to screen and develop chemical probes with differential drug sensitivity profiles of a muscle-invasive prostate cancer cell line. During this period, the team continued to characterize hits that emerged from a screen, of more than 10,000 compounds from oncology-focused and clinically approved libraries, that showed enhanced cytotoxic effects towards muscle-invasive prostate cancer cell lines, relative to parental and diverse prostate cancer cell models. Several classes of compounds with distinct mechanisms of action were tested in follow-up studies. Additionally, a small collection of oncology-focused agents, which were not included in the initial HTS, were screened for ability to selectively kill the muscle invasive cells.