Instrumentation Development and Engineering Application Solutions (IDEAS) Shared Resource

National Institute Of Biomedical Imaging And Bioengineering, Bethesda

Investigators

Linked publications, trials & patents

Abstract

The research and development activities of the Instrumentation Development and Engineering Application Solutions (IDEAS) resource are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodologies. The majority of these collaborations require novel approaches and designs for which there are minimal established criteria or technical knowledge. IDEAS staff have in-depth technical experience in all phases of engineering research and development. With their collaborators, IDEAS staff review the clinical and biomedical sciences to formulate project specifications. IDEAS staff evaluate the theoretical and practical constraints, consider commercially available technologies, and finally propose various solutions. IDEAS responsibilities often continue with the hands-on design, implementation, testing, installation, training, documentation, and production of a custom research system or methodology. Current collaborative projects, as well as associated research studies, include: 1. 3D Printed Cover-Slip Holder for Preserving and Protecting Fixed Cells During Shipment 2. 3D Printed Illustrations Renderings for Vision-impaired Visitors of the Cajal Exhibit 3. 3D Printed Intubation Chamber for Studying Histone Binding Proteins 4. 3D Printed PDMS Wafer Mold for Media Diffusion in Time-course Studies 5. 3D Printing Resource Technology Hub 6. 3D-printed Mold to Cast Microarrays for Spheroid Embedding 7. AR Scientific Data Visualization 8. Adaptor to Hold a 10X Genomics GEM-Generation Chip in Place for Single Cell Sorting 9. Adjustable Inclined Plane for Evaluation of Pediatric Exoskeleton Control Modes 10. Agarose Molding Stamp for High-Throughput Zebrafish Imaging 11. Apparatus for Thermal and Mechanical Perception in Mice 12. Artificial Tick Feeding Chamber 13. Artificial Tick Feeding Chamber - Ornithodoros Hermsi 14. Assessing the Value of 18F-NaF PET-CT to Predict Calcium Content 15. Automated Functional Mapping of Somatosensation 16. Automation of Alcohol Vapor Chambers for Continued Air Supply 17. BETA Center 18. Behavior Box Mouse Whisker Monitoring for Neuronal Circuit Studies 19. Biomechanical Coupling of Skull and Brain for Magnetic Resonance Elastography Experiments 20. Bioreactor for Long-Term Culture of Cerebral Organoids 21. Bone Growth Plate Cartilage Pellet Culture Bioreactor 22. CUP Water Treatment Testing Apparatus 23. Cell Segmentation for Real-Time Measurement of Intracellular Oxygenation Concentration and Metabolism 24. Characterization of the Nociception Phenotype in Individuals with Intellectual Disability (ID) 25. Characterizing Spontaneous Movements in Mouse Pups 26. Conductive Polymer based Microelectroporation for High Efficiency Cell Transfection 27. Correlating MRI and Histopathology Using Patient-specific Prostate Mold 28. Custom Cover for Treating Cells with Light Inside a Multi-Welled Plate 29. Data Acquisition System for Multi-channel Imaging System 30. Development of a Handheld Optical Spectroscopy System 31. Diffusion Exchange Functional MRI 32. Direct Time of Flight (TOF) PET Scanner 33. Dish with a Grid Pattern of Reservoirs to Hold Zebrafish Larvae for Imaging 34. Disinfectant-compatible Storage Solutions for Clinical Equipment 35. Distortion Product Otoacoustic Emissions System 36. EPR Imaging of in vivo Oxygen Status Associated with Cancer Treatment Studies 37. Enrichment Device for Animal Behavior Experiments 38. Etching Array Patterns on Glass Slides for 3D Myotube Culture 39. Evaluation of Extracellular Matrix (ECM) Stiffness Around Tumor Using Atomic Force Microscopy (AFM) 40. Fabrication of Replacement Fittings for Reverse Osmosis Units in ORF Boiler Plant 41. Fabrication of a 3D-printed Ovary Dissection Mold for Gonadal Tissue Histological Study 42. Fixed-Head Mouse Whisker Monitoring for Neuronal Circuit Studies 43. Glymphatics MRI Phantom Development 44. Ground Squirrel Hibernation Automated Behavior Monitoring 45. High-throughput Video-based Assessment of Drosophila - Drug Efficacy 46. Homebased Biosensor for Monitoring COVID-19 Patients 47. Hydrogel-Like Applicator for Treating Surface Cancer on Organs with Complex Topologies 48. Imaging/Interrogation of Metastatic Colonization in Perfused Resected Liver 49. Improved Mosquito Housing Device to Evaluate Consequences of Pyrethroid Resistance Mechanisms on Aedes Aegypti Dengue Infections 50. Improved TUR Device 51. Incubation Chamber for Brain Tissue 52. Incubator for Optogenetic Applications 53. Instrumentation for Spinal Learning Studies 54. Laser Welder GMP for Hyperpolarized MRI 55. Light-sheet Microscopy of Drosophila Motor Neuronal Circuits 56. Liver Perfusion System 57. Low-cost Shoe Design for Pediatric Patients with Lower Extremity Impairments 58. MRI Elastography for Anisotropic Materials 59. Macaque Brain Mold for Histology 60. Machine vision enabled behavioral tracking for cross-species extrapolation 61. Microfluidic PNA-based HIV Detection 62. Mirror Neuron Network Dysfunction as a Biomarker 63. Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder 64. Mouse Cardiac Electrophysiology Recording System 65. Mouse Home-Cage Monitoring Device for Learning and Memory 66. Mouse Illumination System for Retinal Dystrophy Studies 67. Mouse Whisker Stimulation and Tracking During Neural Imaging Experiments 68. Multi-Animal FED Operant Device 69. Noninvasive Multispectral Imaging to Quantitatively Assess Tissue Vasculature 70. OCT - Adaptive Optics Retinal Imaging with Eye Tracking 71. PRiME - Cardiovascular Intervention 72. Placenta Real-time Oximetry Using NIR Spectroscopy 73. Placenta Real-time Oximetry Using Ultrasound and NIR Spectroscopy 74. Portable Low-Field Magnetic Resonance Imager 75. Precise Cell Injection System to Model Immune Cell Recruitment and Engament with Tumor Cells in Peritoneum Tissue 76. Prostate Tumor Fresh Tissue Guided Procurement Methods 77. Quantitative Evaluation of Dynamic Activity of HeLa Cells in Different Viability States Using Dynamic Full-field Optical Coherence Microscopy 78. Rapidscan CW EPR Imaging of Oxygen Status 79. Running Wheel Tachometer 80. SCORHE 81. SCORHE - Phenotyping and Behavioral Assays 82. SCORHE - Phenotyping and Seizure Detection in ATP1A3 Mutated Mice 83. SLO - Adaptive Optics Retinal Imaging with Eye Tracking 84. Signal Amplification by Reversible Exchange (SABRE) 85. Single-Cell Analysis of Rare Virus-Infected and Tumor Cells by FIND-Seq 86. Take-home Device for Handgrip Strength Measurements 87. Tenodesis Type Action Hand Prosthesis for Pediatric Rehabilitation 88. Therapeutic EMFs to Reduce Cell Growth in Glioblastoma Multiforme 89. Tissue Characterization and Oxygenation Measurement 90. Tissue Culture Matrix Casting for Spheroid Growth and Histology 91. Tissue Freezing Cassette 92. Tissue Vacutainer Device 93. UV Crosslinking Device (330nm) to Accurately Map Incorporated 4SU RNA-protein Interactions 94. Vessel Mimetics for Cancer Cell Culture 95. Vestibular Sensory Evoked Potentials System 96. Video Analysis System for Behavior and Activity Assessment of Fruit-Flies in High-Throughput Studies: Rare Genetic Disease Phenotyping 97. Video Monitoring System for Automated Detection of Pain Related Mice Behaviors 98. Video System for Mouse Visual Response Identification 99. Wearable Optical Platform for Assessment of Hemodynamic Changes 100. Whisker holder fixture for Local Field Potential (LFP) recordings 101. X-clometer - New Radiographic Marker 102. Zebrafish Intubation Chamber for Longitudinal Imaging