Imbalanced RF Receive Coil Array for Magnetic Resonance-guided Focused Ultrasound Neuromodulation

Vanderbilt University Medical Center, Nashville TN

Investigators

Abstract

Project Summary/Abstract Magnetic resonance-guided focused ultrasound (MRgFUS) neuromodulation is a groundbreaking, non-invasive therapeutic technique that combines real-time magnetic resonance imaging (MRI) with the precision of focused ultrasound (FUS). It offers a promising alternative to invasive brain stimulation methods for treating neurological -time MRI guidance ensures accurate targeting of brain regions, while MRI thermometry and Acoustic Radiation Force Imaging (ARFI) enable safe monitoring, and functional MRI characterizes the spatial and temporal neural responses to FUS stimulation. However, the effectiveness of MRgFUS neuromodulation is hindered by limitations in signal-to-noise ratio (SNR) or image quality in MRI. The objective of this project is to develop an innovative RF coil array specifically designed for MRgFUS neuromodulation applications. The proposed coil will overcome spatial constraints imposed by the FUS device and water bath, improving SNR and enabling high-quality imaging of human brain, especially deep brain structures such as the thalamus. Key innovations include the use of an imbalanced current/capacitor distribution and irregular coil geometry to maintain high receive sensitivity, even when the coil is displaced from the brain's center. These advancements will enhance the imaging quality of both structural and functional MRI, ensuring more precise and effective therapeutic interventions. The project will involve advanced electromagnetic simulations, the fabrication of coil prototypes, and performance testing. Successful implementation of this novel RF coil array will significantly improve imaging quality in MRgFUS neuromodulation, leading to better patient outcomes, improved patient comfort and expanded clinical applications of this non- invasive treatment for neurological conditions.