Molecular and Cellular Analytical Core

$234,000P30FY2025DKNIH

University Of Colorado Denver, Aurora CO

Investigators

Linked publications, trials & patents

Paper 39642329 Paper 39587896 Paper 39417821 Paper 39372601 Paper 39347985 Paper 39293778 Paper 39131270 Paper 39130192 Paper 39114941 Paper 39114287 Paper 39110324 Paper 39086199 Paper 39065137 Paper 39062861 Paper 39053917 Paper 39010249 Paper 39000037 Paper 38999832 Paper 38999806 Paper 38992061 Paper 38991492 Paper 38979365 Paper 38948245 Paper 38936927 Paper 38931176 Paper 38931163 Paper 38931150 Paper 38929210 Paper 38918734 Paper 38917457 Paper 38915393 Paper 38913861 Paper 38913742 Paper 38905488 Paper 38896452 Paper 38894879 Paper 38884255 Paper 38879688 Paper 38871238 Paper 38863587 Paper 38850506 Paper 38838803 Paper 38828481 Paper 38826380 Paper 38816203 Paper 38796448 Paper 38793899 Paper 38787341 Paper 38781013 Paper 38766233 Paper 38764894 Paper 38756206 Paper 38750219 Paper 38743350 Paper 38741246 Paper 38735637 Paper 38727325 Paper 38722414 Paper 38713613 Paper 38711335 Paper 38707825 Paper 38701776 Paper 38695352 Paper 38693412 Paper 38692428 Paper 38690735 Paper 38687612 Paper 38687595 Paper 38684100 Paper 38670920 Paper 38653860 Paper 38639997 Paper 38637889 Paper 38625699 Paper 38621624 Paper 38613046 Paper 38607340 Paper 38604285 Paper 38601267 Paper 38595204 Paper 38584515 Paper 38583602 Paper 38574894 Paper 38568091 Paper 38562855 Paper 38562766 Paper 38562129 Paper 38552340 Paper 38551326 Paper 38536037 Paper 38535623 Paper 38515583 Paper 38496569 Paper 38477875 Paper 38455512 Paper 38451784 Trial NCT06496542 Trial NCT05984043 Trial NCT04095104 Trial NCT02347527

Abstract

PROJECT SUMMARY â MOLECULAR AND CELLULAR ANALYTICAL CORE The overall objective of the Molecular and Cellular Analytical (MCA) core is to support investigation of human and non-human metabolism from a cellular and molecular perspective. The MCA Core will provide expertise, facilities, and equipment for 1) mass spectrometry (MS) applications in lipidomics and isotope enrichment; 2) genomic and transcriptomics; and 3) cellular respiration and mitochondrial function. The leadership team (Drs. Bryan Bergman, Kartik Shankar, Matthew Jackman, and Karin Zemski Berry) bring a wealth of expertise in nutrition, obesity, and metabolic research. The lipidomic and mass spectrometry component provides quantitative lipidomic analysis on plasma, cells, and tissues, as well as help with data interpretation, in addition to determination of isotope enrichment and concentration of metabolites in blood and breath used in isotope tracer studies. The genomics and transcriptomics component has established a nutrition- and obesity- informed conduit for NORC Members to access and apply Next Generation Sequencing to their research, which includes nucleic acid extraction, advanced computational processing, and pathway, network, disease, and regulator discovery tools for RNAseq and related sequencing experiments. The cellular/mitochondrial function component provides expertise and access to core equipment that can measure respiration and molecular aspects of cells and isolated mitochondria. Over the past 5 years, the MCA Core established an excellent track record of productivity and a substantive institutional investment to support nutrition and obesity research. The MCA Core now plans to leverage a renewed institutional investment to sustain its valuable operations, adapt to the evolving needs of its research base, and facilitate the advancement of science of nutrition and obesity through its efforts in the Rocky Mountain region.

View original record on NIH RePORTER →