Proteomics Core

$135,380P30FY2025EYNIH

Oregon Health & Science University, Portland OR

Investigators

Linked publications, trials & patents

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Abstract

Proteomics Core - Project Summary This National Eye Institute-funded Proteomics Core aims to use modern technologies in the field of proteomics to discover the causes and improve treatments for eye diseases, including cataract, glaucoma, retinal disease, and corneal pain. Proteomic analyses will be performed with the specific aims of measuring changes in protein abundance and modification with disease, determining how proteins fold and interact with one another, and how they regulate development. The methods used will include tandem mass tagging to detect proteins undergoing changes in abundance, phosphopeptide analysis to discover mechanisms controlling cellular processes, non- restrictive searches to detect post-translational modifications, hydrogen-deuterium exchange and chemical cross-linking to determine structure. The results will complement data generated by the other cores supported by this P30 grant to increase the productivity of vision researchers at OHSU and devise better treatments for eye disease. Dr. Lampi will continue in her role as co-Director, while addition of Dr. Reddy as co-Director will broaden the reach of this core by providing increased support for experimental design, instrument operation, and development of new sample preparation protocols.

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