Squirrel Monkey Breeding and Research Resource

University Of Tx Md Anderson Can Ctr, Houston TX

Investigators

Linked publications & trials

Abstract

PROJECT SUMMARY: OVERALL COMPONENT This application is a competing renewal of the “Squirrel Monkey Breeding and Research Resource” (SMBRR) P40 OD010938 which has received continuous NIH grant support since 1980. The SMBRR is the only national research resource of squirrel monkeys available to NIH grantees, intramural research programs of federal agencies including the FDA, NSF, and the NIH, and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Because Bolivian squirrel monkeys are no longer available from source countries, and there are no other breeding colonies of pedigreed squirrel monkeys available for biomedical research, the SMBRR is a unique research resource that cannot be duplicated or replaced. The scarcity of squirrel monkeys, difficulties associated with captive breeding, as well as the challenges associated with their care and use in research, all contribute to the need for this nationalresearch resource. The SMBRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. In the upcoming years, the SMBRR will continue to improve the resources it provides and continue to add new information about the biology and research value of squirrel monkeys. Squirrel monkeys continue to be an important animal model in neuroscience research, drug addiction research, malaria vaccine research, and fundamental evolutionary biology. Over the next five years,the SMBRR will focus on refining the animals and related resources to meet the needs of the scientific community. The aims of the Resource Core Component address our continued commitment to meeting the needs of the research community for access to squirrel monkeys and information about using squirrel monkeysin research. We will explore the causes of perinatal mortality in a retrospective epidemiology study as well as the potential role of different genes. We will expand our biobanking program to prioritize collection of frozen and formalin-fixed tissued for use in molecular biological and gene expression studies (both bulk and single nuclei approaches). The Applied Component research projects focus on basic research projects that will enhance to use of the SMBRR and provide data on best practices and uses of different anesthetics on brain and behavior. The Curation and Informatics Component is designed to simplify access to SMBRR materials by the scientific community and to facilitate accurate documentation of its use. The overall goals of the SMBRR are to provide a national research resource of squirrel monkeys; provide squirrel monkey derived biological materials; provide education and training opportunities to scientists wishing to workwith squirrel monkeys, colony managers, and animal caregivers; and provide investigators with facilities and expertise to conduct studies using squirrel monkeys.