Admin Supplement to "Breaking up sedentary behaviors to improve glucose control in a population at risk for developing type 2 diabetes"

University Of Colorado Denver, Aurora CO

Investigators

Linked publications, trials & patents

Abstract

SUMMARY/ABSTRACT This proposal requests supplemental funding to support the ongoing NIH/NIDDK-funded R01 project (DK123334), which was initiated in December 2020 for a five-year period. The parent study aims to compare the 4-week effects of frequent, short bouts of physical activity (PA) designed to interrupt prolonged sedentary behavior (SB, i.e., sitting) versus a single continuous daily PA bout of equal total duration, focusing on their impact on glucose control and the underlying mechanisms in adults with prediabetes. The PI, a mid-career researcher, faced significant challenges during the initial years of this R01, including launching a new clinical research study and assembling a team during the COVID-19 pandemic, as well as navigating the demands of new parenthood following the birth of her first child in Spring 2022. These factors inevitably impacted her work productivity. Despite these challenges, the study has successfully randomized 35 out of the planned 66 participants, with primary outcome data collection completed for 32 participants. Additional pilot grants have enabled the extension of the intervention from 4 weeks to 12 weeks, along with a 3-month follow-up and expanded data collection. With over 60% of the data now collected, the focus is shifting to the critical tasks of creating a central database, data cleaning, and analysis to accelerate the generation of interpretable preliminary data. The supplemental funding is sought to hire a new PRA with skills and experience in database management, data cleaning, coding, and analyses. Three specific aims will be addressed. Aim 1 involves the analysis and interpretation of daily PA and SB data, along with 24-hour glycemic variability, including an exploratory analysis to better understand the interaction of these factors in free-living conditions. Aim 2 focuses on the analysis of 24-hour substrate oxidation and glucose kinetics using the combination of whole-room calorimetry and a dual- tracer technique to explore how different PA patterns influence glucose metabolism. Aim 3 proposes to explore whether distinct glycemic phenotypes are associated with changes in traditional markers of glucose metabolism following the interventions, potentially leading to personalized strategies for T2D prevention. This funding is crucial for accelerating data analysis, facilitating the timely dissemination of findings, and generating the preliminary data necessary to develop a new, competitive R01 proposal. It will also give the PI the time needed to focus on manuscript preparation and grant writing, thereby advancing her project and ensuring her retention and success in academia. Ultimately, these data will contribute to scientific and public health efforts aimed at optimizing PA interventions for T2D prevention.