GGrantIndex
← Search

FUNCTIONAL ROLE OF ETS1 AND AKT IN ANGIOGENESIS

$0P20FY2002RRNIH

Medical University Of South Carolina, Charleston SC

Investigators

Linked publications & trials

Abstract

DESCRIPTION (provided by applicant): Dr. Muise-Helmericks proposes to delineate the molecular mechanisms by which the potent vascular endothelial growth factor (VEGF) stimulates formation of new blood vessels. Her specific hypothesis, based on preliminary studies that included gene microarrays, is that the P13 kinase/Akt pathway is a general control point that mediates different angiogenic signals (e.g. FGF, VEGF), and that Ets-1 is a central downstream effector of this pathway.

View original record on NIH RePORTER →