BCL2 /BAX REGULATION OF APOPTOSIS IN CV PATHOLOGY

$0P20FY2002RRNIH

Medical University Of South Carolina, Charleston SC

Investigators

Linked publications & trials

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Abstract

DESCRIPTION (provided by applicant): The long-range goal for Dr. Hsu's project is to understand how Blc and Bax family members regulate cell death in various cardiovascular pathogenic pathways in order to eventually enable development of cardioprotective agents. He will use his considerable expertise to test the central hypothesis he pioneered: that Bcl-2 and Bcl-X block the pro-apoptotic function of Bax by preventing its redistribution from the cytosol to mitochondria during apoptosis, possibly through their respective mitochondrial receptors.

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