UCSF Type 1 Diabetes Research Center

University Of California, San Francisco, San Francisco CA

Investigators

Abstract

Overall Summary The University of California at San Francisco Diabetes Research Center (DRC) will function as a basic and clinical research enterprise at the forefront of type 1 diabetes (T1D) research. The DRC crosses the boundaries of Departments and Schools to support a highly interactive team investigating all forms of diabetes to advance the understanding and treatment of the disease. The DRC integrates the research activities of the UCSF Diabetes Center, the administrative home of the DRC, with a broad range of diabetes-related research throughout UCSF. The combined intellectual and research expertise of the DRC encompasses 43 diabetes investigators from UCSF, UC Berkeley, and UC Davis, focused on both basic and clinical research, supported with $22M in annual direct costs in diabetes-related grant funding, including $12M in Federal funding. In this application, we propose to continue the success of the UCSF DRC in promoting, enhancing and integrating T1D research at UCSF. That goal is realized through support for the following activities: Administrative Core provides leadership, infrastructure, administrative support, advice and oversight to the other components and members of the DRC; regularly adapts Cores and programs to fit the needs of the members; and interfaces with the NIDDK, other NIH Diabetes Centers, and the lay community. Enrichment Program organized by the Administrative Core supports DRC members and the regional diabetes research community by enhancing scientific exchange and training with seminar series, invited speakers, and an annual retreat. Biomedical Medical Research Cores Islet Core: Provides mouse and human islets and technologies for working with those islets, together with expertise, advice and training. Flow and Mass Cytometry Core: Provides equipment, assistance and training for human and animal cell analyses. Microscopy Core: Provides advanced imaging equipment, technologies, advice and training. Pilot & Feasibility Program funding small innovative projects that support new investigators, attract new investigators to diabetes and the DRC, explore new questions by established investigators, and promotes interactions and collaborations leading to new external funding support to further goals of the DRC.