Tissue Procurement, Processing and Phenotyping Core

University Of Colorado Denver, Aurora CO

Investigators

Linked publications & trials

Abstract

Summary Abstract The Tissue Procurement, Processing & Phenotyping (TPPP) Core at the University of Colorado Anschutz Medical Campus is seeking renewed funding to continue its mission of accelerating cutting-edge diabetes research. As an integral component of the Diabetes Research Center (DRC), the TPPP Core provides centralized access to high-quality tissues, cells, and state-of-the-art histology services, enabling investigators to unravel the complexities of diabetes pathogenesis and develop innovative therapies. Building upon a strong track record of success, the TPPP Core aims to enhance its rodent and human islet and tissue procurement services, ensuring a reliable supply of well-characterized samples for diverse diabetes research needs. Through collaborations with leading institutions and programs, such as the Integrated Islet Distribution Program (IIDP) and the University of Alberta, the core will expand access to valuable human islet samples. Additionally, the establishment of a streamlined pipeline for human tissue acquisition from the Pathology Department will facilitate the procurement of pancreatic, adipose, and other relevant tissues. The core's comprehensive histopathology services, coupled with access to specialized equipment and expert consultation, will empower researchers to employ cutting-edge methodologies in their studies. Furthermore, the introduction of a state-of-the-art perifusion analysis service as well as vibratome sectioning for three-dimensional imaging of pancreatic islets will provide valuable insights into islet and endocrine cell function and differentiation. Recognizing the importance of collaboration and resource sharing, the TPPP Core will enhance its diabetes-relevant cell line repository and distribution services. By curating a diverse collection of authenticated cell lines and implementing rigorous quality control measures, the core will ensure the integrity and reliability of these valuable research tools. The streamlined distribution process and comprehensive technical support will foster collaboration among DRC members and accelerate scientific progress. Throughout its operations, the TPPP Core will prioritize training, education, and mentorship, supporting the next generation of diabetes researchers. By working closely with other DRC cores and leveraging institutional resources, the TPPP Core will create a synergistic environment that promotes multidisciplinary research and catalyzes transformative discoveries.