Neuropathlogy Core

$442,346P30FY2025AGNIH

Stanford University, Stanford CA

Investigators

Linked publications & trials

Paper 39711699 Paper 39677464 Paper 39649607 Paper 39574639 Paper 39554163 Paper 39503843 Paper 39496718 Paper 39496102 Paper 39483910 Paper 39444005 Paper 39428957 Paper 39399688 Paper 39371140 Paper 39365322 Paper 39352226 Paper 39340798 Paper 39314957 Paper 39294787 Paper 39276722 Paper 39217398 Paper 39195563 Paper 39185475 Paper 39149241 Paper 39137265 Paper 39080151 Paper 39077866 Paper 39072037 Paper 39055313 Paper 39011113 Paper 38974877 Paper 38965435 Paper 38962867 Paper 38943387 Paper 38915561 Paper 38903124 Paper 38896163 Paper 38888142 Paper 38883718 Paper 38859733 Paper 38853828 Paper 38788065 Paper 38780681 Paper 38779814 Paper 38768342 Paper 38759012 Paper 38755756 Paper 38753380 Paper 38746455 Paper 38746437 Paper 38712073 Paper 38632391 Paper 38617345 Paper 38612729 Paper 38602280 Paper 38598986 Paper 38585781 Paper 38574399 Paper 38559129 Paper 38539014 Paper 38526701 Paper 38520489 Paper 38507374 Paper 38480892 Paper 38467937 Paper 38464202 Paper 38463500 Paper 38460116 Paper 38436140 Paper 38425134 Paper 38390561 Paper 38380866 Paper 38374692 Paper 38364295 Paper 38355598 Paper 38353367 Paper 38348782 Paper 38348772 Paper 38345347 Paper 38340719 Paper 38312309 Paper 38310122 Paper 38302557 Paper 38301647 Paper 38298163 Paper 38296755 Paper 38267190 Paper 38243325 Paper 38230729 Paper 38222248 Paper 38184787 Paper 38176356 Paper 38146099 Paper 38134931 Paper 38083699 Paper 38057571 Paper 38053483 Paper 38040087 Paper 38034852 Paper 38014176 Paper 38014121

Abstract

SUMMARY NEUROPATHOLOGY CORE The Neuropathology Core supports the vision of the Stanford Alzheimer's Disease Research Center (ADRC) by serving as a shared resource to facilitate and enhance multidisciplinary and interdisciplinary research in Alzheimer's disease (AD) and Lewy Body Disease (LBD). It aims to continue providing comprehensive postmortem examinations and brain banking, ensuring adequate tissue preservation for high-content imaging and multiomics technologies. The Neuropathology Coreâs mission is realized through five specific aims. Aim 1 focuses on providing comprehensive neuropathological evaluations for ADRC participants, well-documented dementia patients followed by Stanford Neurology clinicians, clinical trial participants, and healthy controls. Aim 2 involves maintaining and expanding a biorepository of fresh-frozen, short-fixed, and formalin-fixed paraffin- embedded brain tissue from patients within the AD spectrum, LBD spectrum, and cognitively normal individuals, employing methods that maximize tissue quality. Aim 3 supports interdisciplinary research by facilitating the application of cutting-edge and high-content technologies, particularly multiomics techniques, to both fresh-frozen and fixed postmortem brain tissue samples. Additionally, the core aims to support digital pathology research for quantitative neuropathology, including harmonizing data with other centers to enhance tissue sharing. Aim 4 supports a newly established ADRC Stem Cell Program to provide the community with deeply characterized human induced pluripotent stem cells, augment their use by genetic engineering to make the lines more user-friendly for downstream neuronal modeling, and generate a biobank of neuronal progenitors and early organoids for pilot studies. Aim 5 emphasizes training, maintaining a rich environment for trainees and faculty and providing education in neuropathology, clinico-pathological correlations, and state-of- the-art techniques. Several new training modules for iPSC derivation and modeling will be provided. Through these aims, the Neuropathology Core is instrumental in bridging research, discovery, and clinical domains, ultimately contributing to a deeper understanding of AD and related disorders.

View original record on NIH RePORTER →