The Goizueta Alzheimer's Disease Research Center

Emory University, Atlanta GA

Investigators

Linked publications & trials

Abstract

SUMMARY/ABSTRACT: BIOMARKER CORE SUMMARY/ABSTRACT: BIOMARKER CORE The primary goals of the Biomarker Core are to support and enhance research activities both inside and outside the Emory Goizueta Alzheimer’s Disease Research Center (GADRC) by 1) supporting standardized biospecimen collection and preparation using best practices, 2) completing a set of standard analyses for genetics and AD biomarker assays in CSF and plasma, and 3) measuring emerging plasma and CSF biomarkers of disease. The standard genetics and biomarker assays will facilitate identification of at-risk individuals and confirm AD-related pathology in symptomatic individuals. To facilitate research into the complexity and heterogeneity of AD/ADRD, the Core will foster research to understand emerging biomarkers and their performance in diverse populations. Longitudinal collection of common datasets, including clinical information, CSF AD biomarkers, and genetic ancestry and polygenic risk scores, will provide foundations upon which new and existing AD/ADRD biomarkers can be tested, evaluated, and confirmed. Exploratory research in each of these areas should provide significant advances in CSF proteomic, plasma proteomic, and genomic biomarkers. To accomplish these aims, the Core engages a group of talented investigators who will bring their expertise to the GADRC and the larger research community. Each of these elements advance the overall goals of the GADRC and will provide a wealth of data for new trainees.