Core B - Clinical Core

$952,952P30FY2025AGNIH

Icahn School Of Medicine At Mount Sinai, New York NY

Investigators

Linked publications, trials & patents

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Abstract

Mount Sinai ADRC (Sano): Clinical Core (Core B) â Research Summary The Clinical Core provides expertise in the clinical and biological characterization of diverse individuals with and without cognitive loss. This expertise is utilized to recruit and maintain a cohort of participants of varying clinical presentations, educational attainment, races and ethnicities. This cohort supports a broad array of dementia and cognitive research conducted within ISMMS, the Mount Sinai Health System, and national initiatives such as the National Alzheimerâs Coordinating Center (NACC), Alzheimer's Therapeutic Research Institute (ATRI), Alzheimerâs Clinical Trials Consortium (ACTC), Alzheimerâs Disease Cooperative Studies (ADCS), the Alzheimerâs Disease Neuroimaging Initiative (ADNI). The role of the core is to develop and implement clinical procedures and collect biomarkers for the high standard characterization of elders spanning the spectrum of normal, prodromal, and various stages of affected subjects into âresearch-readyâ cohorts. The Clinical Core provides subjects, tissue, and data for studies as well as clinical research expertise related to clinical manifestations of disease, disease course, treatment responses, and recruitment feasibility to help guide the design and implementation of studies within the Center and broadly within the MSHS. Within the Center, the Clinical Core provides the essentials for research: the subjects and characterization for the Imaging Biomarker and Genetics Fluid Biomarker Cores as well as the Neuropathology Core; clinical and educational expertise to interact with the projects and trainees of the ORE and REC cores. The Core innovates in the development of assessment tools; application of assessments to new populations; adaptation of new imaging technologies into the clinical âreal worldâ; and facilitates work with clinical trials. The Core has a rich and successful history of outreach to groups underrepresented in dementia research which remains a focus of this application. The Core is active in training young investigators and supporting investigators from other fields who wish to study cognition in their clinical populations.

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