Genomics Shared Resource (GSR)

University Of California Los Angeles, Los Angeles CA

Investigators

Linked publications & trials

Abstract

GENOMICS SHARED RESOURCE (GSR) ABSTRACT The objective of the UCLA Jonsson Comprehensive Cancer Center (JCCC) Genomics Shared Resource (GSR) is to enable and enhance members’ cancer research. This objective is being achieved through mechanisms that group into: (1) Developing state-of-the-art next generation sequencing (NGS) technologies, services, and solutions; (2) Fostering interdisciplinary collaborations and interactions; (3) Providing ready access to technologies, services, and scientific consultations; and (4) Furthering productivity to maximize the scientific impact of JCCC investigator research. GSR management within the JCCC is led by Associate Director of Shared Resources Zoran Galic, PhD (TII), and a four-member GSR Faculty Advisory Committee (FAC), in collaboration with Elaine Reed, PhD, Endowed Chair in Diagnostic Medicine, Professor of Pathology and Laboratory Medicine and Director of the UCLA Immunogenetics Center. Under the leadership of GSR Director Xinmin Li, PhD (ERGR), and Co-Director Hyun-Ju Lim, PhD, GSR has a highly trained team of 18 genomics and bioinformatics staff, including nine PhD scientists. Housed within GSR are cutting-edge genomics technologies including a Novaseq X plus sequencer, DNBseq T7 sequencer, GridION long sequencer, 10X Chromium IX and BD Rhapsody single cell systems, a 10X Visium CytAssist, a 10X Xenium Analyzer, a GeoMx Digital Spatial Profiler, a CosMx Spatial Molecular Imager, a 10X Genomics Chromium Connect, a Beckman Coulter Biomek i7, and a Life Tech EVOS M7000 microscope. Empowered by these recent technological innovations and capabilities, GSR provides >70 different genomics menu services, including bulk, single cell, and spatial multi-omics analyses and data management that are timely and cost-effective. GSR services are prioritized for JCCC members. GSR also offers alternative platforms for major technologies tailored to meet specific scientific requirements. This variety of capabilities enable JCCC investigators to tackle a wide range of complex and multifaceted questions. From 2019 – 2023, GSR served 111 different JCCC investigators from all six JCCC Research Programs. In addition to providing services, GSR supports JCCC investigator labs with education, consultation, expertise, and innovation. Since 2019, GSR has offered 31 lectures, seminars, and workshops with approximate attendance by JCCC members ~650 times at these events. Li has written >130 grant support letters, with approximately 18% funded, and has provided expert revisions for numerous manuscripts and grant applications. This multidimensional support resulted in impressive scientific and financial impact, with GSR support contributing to 226 publications with 55% appearing in high-impact (IF >10) journals, newly awarded extramural grants totaling $193M, and 21 patent applications from 2019 – 2023. GSR has consistently shown and will continuously make impactful contributions to JCCC cancer research, which prioritizes the needs of its Los Angeles County catchment area residents.