Transgenic Mouse Core

Boston Children'S Hospital, Boston MA

Investigators

Abstract

Core 3. Transgenic Mouse Core Abstract Genetically engineered mice have been essential tools to study the function of immune genes in mammals. To support the overall goals of the “Immunization against Multidrug-resistant Pathogens: Activating T Cell Immunity” Center of Excellence for Translational Research (IMPACT-CETR) and to control for the gut microbiota that could influence results, we have centralized breeding of mice in the Transgenic Mouse Core. The Transgenic Mouse will supply genetically engineered mice for the research projects. The overall coordination of breeding animals will be through this core. Specific Aims are: 1) To monitor and maintain genetically engineered lines for the projects. 2) To coordinate breeding and shipment demands with the project leaders. 3) To provide assay support for genotyping as well as tissue specific recombination for conditional knockout lines.