Prevalence, etiology, and clinical implications of low count monoclonal B-cell lymphocytosis (MBL)

Mayo Clinic Rochester, Rochester MN

Investigators

Abstract

Monoclonal B-cell lymphocytosis (MBL) is one of the most common malignant precursor conditions, affecting 8-10 million adults >40 years of age in the United States. MBL is defined by the presence of a clonal B-cell population in the blood with sub-classification based on the immunophenotype of the cell surface markers and the size of the B-cell clone: low-count MBL (LCMBL) is defined as clonal B-cell count <0.5 x109 cells/L and high-count MBL (HCMBL) as clonal B-cell count between 0.5 and 5x109/L. Of clinical and