SIGNALS THAT PATTERN THE ANTERIOR CENTRAL NERVOUS SYSTEM

$276,699P01FY2002HDNIH

University Of Oregon, Eugene OR

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Abstract

Previous studies implicate members of the Hedgehog (Hh) and Nodal signaling pathways in specification of the anterior central nervous system (CNS). The proposed studies are based on a specific hypothesis that postulates that Nodal and Hh signaling systems interact in a network. Experiments will test this hypothesis by analyzing loss and gain of function of components in both the Nodal and Hh pathways and by identifying the regulators of these pathways in a forward genetics mutagenesis screen.

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