Microphysiological systems to Advance Precision medicine for Alzheimer's Disease and Related Dementias (MAP-AD)

Indiana University Indianapolis, Indianapolis IN

Investigators

Abstract

PROJECT ABSTRACT/SUMMARY Administrative and Data Management (ADM) Core The Administrative and Data Management (ADM) Core will oversee all administrative and scientific functions of the IU MAP-AD Center. The ADMIN Core will be led by Dr. Jason Meyer with assistance from Co-PIs Dr. Bruce Lamb and Dr. Donna Wilcock, leveraging input from PIs from the other associated Cores. The ADMIN Core will also be guided by input and suggestions from an External Advisory Board (EAB) and a Center Steering Committee (CSC). Based upon previous expertise obtained through ADMIN Cores associated with MODEL-AD, TREAT-AD, and CLEAR-AD Centers at Indiana University, we propose that the ADM Core of the IU MAP-AD Center will provide oversight in four key areas: 1) coordinating the activities and interactions of associated investigators and communication with NIA; 2) establishing benchmarks for success, monitoring projects/cores for bottlenecks, implementing alternative strategies/tactics to ensure success; 3) providing effective oversight of data management among the cores of the IU MAP-AD Center as a whole; and 4) ensuring the effective dissemination of research resources, datasets, and protocols for implementation within the research community. In the formation of our IU MAP-AD team, we have placed a strong emphasis upon the integration of this Center with ongoing NIA-supported Centers at IUSM, including the Indiana ADRC, MODEL- AD, TREAT-AD, and NCRAD, among others. The specific aims of our current application are well-integrated with the ongoing work of these existing centers, extending the impact of our work in a complimentary manner to other NIA-funded initiatives. Our group also has a strong track record in open-science initiatives, which will greatly enable the rapid translation of our results and MPS models for broader use within the scientific community.