GROWTH CONE ACTIVITY AND NEURONAL PLASTICITY

$143,176P01FY2002HDNIH

University Of Iowa, Iowa City IA

Investigators

Linked publications & trials

Paper 19863269 Paper 19768439 Paper 19763985 Paper 19633268 Paper 19363786 Paper 19349035 Paper 19209824 Paper 19101836 Paper 18840613 Paper 18540882 Paper 18539401 Paper 18428031 Paper 18044718 Paper 18025308 Paper 18003840 Paper 17623773 Paper 17464797 Paper 17267561 Paper 17079336 Paper 16957296 Paper 16919393 Paper 16890490 Paper 16854366 Paper 16800003 Paper 16763031 Paper 16479376 Paper 16452672 Paper 16410554 Paper 16236705 Paper 15855234 Paper 15821137 Paper 15763995 Paper 15476260 Paper 15370196 Paper 15340009 Paper 15226374 Paper 15189986 Paper 14978721 Paper 14743349 Paper 14742507 Paper 14727189 Paper 14673076 Paper 14532423 Paper 13129848 Paper 12953059 Paper 12952065 Paper 12905529 Paper 12613668 Paper 12582123 Paper 12382260 Paper 12211111 Paper 12198158 Paper 12105844 Paper 12049457 Paper 11977985 Paper 11950890 Paper 11331973 Paper 11190516 Paper 11157987 Paper 10958392 Paper 10930471 Paper 10871039 Paper 10729343 Paper 10700454 Paper 10666227 Paper 10658208 Paper 10591622

Abstract

DESCRIPTION: These proposed experiments will combine genetic, cell biological and physiological approaches to study the development and plasticity of neuronal connections. Cultured neurons from Drosophila mutants that express defects in axonal navigation, nerve terminal arborization and synaptic plasticity will be used to focus on studies of the dynamic regulation of the growth cone cytoskeleton, membrane vesicle cycling, and cell adhesion by second messengers and protein kinases. The DIAS analysis system will be used to detect abnormal motility and related behaviors of growth cones from mutant neurons, and a fourth aim will also use DIAS to identify abnormal locomotory behaviors of mutant fly larvae.

View original record on NIH RePORTER →