Viral Testing Core

Oregon Health & Science University, Portland OR

Investigators

Linked publications, trials & patents

Abstract

PROJECT SUMMARY - Core B: Viral Testing Core Genetically characterized rhesus macaques that are free of endemic viral pathogens have become the premier animal model for HIV/AIDS research, including studies on HIV pathogenesis, AIDS-related opportunistic infections, as well as the development of HIV treatments and vaccines. The establishment of specific pathogen-free (SPF) colonies also serves to protect animal caretakers from zoonotic diseases and improves overall animal health. However, the successful derivation and maintenance of SPF colonies is challenging and requires strict surveillance regimens over long periods of time. Therefore, the overall aim of the Viral Testing Core is to provide appropriate pathogen surveillance and implement state-of-the-art testing services, in order to maintain our breeding colony is specific pathogen free and provide surveillance and antibiotic stewardship interventions for common pathogens affecting the health of the colony. To do this, we will use proven virus screening algorithms combined with an expanding arsenal of screening assays, rapid multiplex molecular panel testing, and antibiotic stewardship interventions. A central strategy to achieve this will be the implementation of a multiplexed protein microarray assay platform for routine colony screening, which we have developed and validated at our Center, and the rapid multiplex PCR testing which is being validated for NHPs at our Center.