Project 1: Novel gene networks modulating progressive ethanol consumption in DO mice

$196,005P50FY2025AANIH

Virginia Commonwealth University, Richmond VA

Investigators

Linked publications, trials & patents

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Abstract

Project Summary â Pilot Projects The goals of this Pilot Projects Core of the VCU Alcohol Research Center (ARC) are to: 1) manage the progress and quality control for our two designated initial pilot projects, 2) solicit and evaluate future pilot grant proposals to further expand the scientific breadth of VCU-ARC, 3) encourage pilot grant awardees to submit proposals for independent funding and 4) support training opportunities for students and postdoctoral fellows within laboratories of funded pilot projects. The first proposed Pilot Project is entitled âInvestigating the relationship between alcohol use, blood pressure phenotypes, and geneticsâ and will be led by Dr. Elvin Price, a clinical pharmacologist and translational researcher with extensive training in pharmacogenomics. He will determine if tag SNPs in VCU-ARC genes of interest impact drinking behaviors and cardiovascular disease phenotypes in a local cohort recruited from the community through the established Translational Approaches to Personalized Health (TAPH) study. This project will interact with Project 1, led by Dr. Michael F. Miles, and Project 3, led by Dr. Amy Lasek. Pilot Project 1 will also interface with the human genetics studies proposed in Projects 4 (Dr. Dick) and 5 (Drs. Riley, Bacanu, and Nguyen) as new genes influencing the risk for AUD are identified. The second targeted pilot, entitled âAssess the influence of select dynamic non-SNV genomic variation on AUD risk and alcohol related outcomes using existing biobank resources including UK Biobank and All of Usâ will be conducted by Dr. B. Todd Webb, an expert in using statistical genetics, bioinformatics, and computational genomic tools to understand the genetic architecture of complex human diseases such as AUD. He will focus on the role of telomere length and mitochondrial abundance as indices of dynamic variation in AUD-related phenotypes. Project 2 will interface with Projects 4 and 5. We will solicit other proposals in year 2 and fund the two best of them in years 3-4, then solicit proposals again in year 4 to fund one in year 5. The pilot program is an important component of the VCU-ARC that will enable us to attract new and innovative researchers to interact with Center investigators and expand high quality alcohol research at VCU.

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