Yale Cooperative Center of Excellence in Hematology

Yale University, New Haven CT

Investigators

Linked publications & trials

Abstract

RESEARCH SUMMARY The mission of the Yale CCEH is to facilitate, enhance, and promote research in hematopoiesis, stem cell biology, and other nonmalignant hematology-related areas. The YCCEH’s unique focus is the application of innovative, emerging technologies to study of normal and perturbed hematopoiesis. We have recently made substantial progress towards the mission with three technology cores (Cell Prep, Imaging and Animal) that have led to nonmalignant studies published in high impact journals, supported awarding of major grants, and trained the next generation of nonmalignant hematology researchers. We now propose to add further cutting edge technology and much needed clinical samples to the basic cores to further enhance studies and innovation. Specific Aim #1 will add single platelet characterization to complement the technologies provided by the Cell Preparation and Analysis Core. Specific Aim #2 will complement the Animal Modeling Core with key human nonmalignant hematology samples and Specific Aim #3 will add the most recent FLASH-PAINT technologies to the Imaging core. All these additions have been recently peer reviewed and published in high impact journals. To continue the success of the YCCEH, technology and resources must evolve to be at the forefront of discovery. The current administrative supplement proposal will maintain YCCEH as an international leader in technology resources for nonmalignant hematology research.