Cardiovascular Health and Inflammation: Intersectional Impact of Structural Racism, Structural Sexism, and Structural Classism

$257,504P20FY2024GMNIH

University Of Vermont & St Agric College, Burlington VT

Investigators

Linked publications, trials & patents

Paper 39661063 Paper 39606730 Paper 39375369 Paper 39192871 Paper 39162287 Paper 39157749 Paper 39081743 Paper 38934871 Paper 38817635 Paper 38584975 Paper 38483507 Paper 38482689 Paper 38446016 Paper 38444160 Paper 38420777 Paper 38358396 Paper 38237104 Paper 38078532 Paper 38019989 Paper 38003472 Paper 37925376 Paper 37923195 Paper 37863105 Paper 37745396 Paper 37729616 Paper 37645923 Paper 37561136 Paper 37549299 Paper 37531033 Paper 37491483 Paper 37405700 Paper 37300451 Paper 37260023 Paper 36802432 Paper 36778750 Paper 36751860 Paper 36744541 Paper 36638232 Paper 36621640 Paper 36583082 Paper 36581970 Paper 36526374 Paper 36522626 Paper 35970010 Paper 35894970 Paper 35844146 Paper 35727988 Paper 35595375 Paper 35549371 Paper 35473919 Paper 35385769 Paper 35382561 Paper 35349300 Paper 35330927 Paper 35264422 Paper 35259637 Paper 35254866 Paper 34896817 Paper 34895192 Paper 34794173 Paper 34585257 Paper 34568829 Paper 34351870 Paper 34325516 Paper 34290098 Paper 34168571 Paper 34139632 Paper 34075043 Paper 33990104 Paper 33882948 Paper 33875602 Paper 33848732 Paper 33763649 Paper 33504187 Paper 33470899 Paper 33382815 Paper 33104469 Paper 33043232 Trial NCT05004389

Abstract

Poor cardiovascular health (CVH) causes cardiovascular diseases (CVDs), and there is growing evidence that inflammation links poor CVH to higher risk of CVD. In the United States, there are disparities in CVH and levels of inflammatory biomarkers by race, gender, and socio-economic status. According to the intersectionality theory, health inequities do not arise solely from individual social identities (i.e., race, gender, and socio-economic status) but result from interrelations of individual social identities and structural oppressions (structural racism, structural sexism, and structural classism). To date, no study we are aware of has used an intersectional perspective to investigate effects of structural oppressions, alongside individual social identities, on overall CVH or on inflammation. We will use intersectional approaches to understand associations of structural oppressions with CVH and inflammation in Black and White women and men of the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study. REGARDS is a longitudinal study of 30,239 Black and White adults (45 and older) from 1,860 of 3,000 US counties. The proposed aims are to: 1) determine the intersectional impact of structural racism, structural sexism, and structural classism on CVH in Black and White men and women over 10 years; 2) Identify intersectional associations of structural racism, structural sexism, and structural classism with inflammatory biomarkers measured in Black and White men and women after 10 years. To complete these aims, we will create composite indices of structural oppressions at the REGARDS baseline visit and analyze their intersectional associations with longitudinal CVH data and 92 inflammatory biomarkers measured in Visit 2 samples. Inflammatory biomarkers will be measured using targeted proteomics in the VCCBH Study Design and Molecular Epidemiology Core (Core B). Results of this research may inform future preventive measures and policies to address CVH inequities and advance knowledge on the biological embodiment of structural oppressions.

View original record on NIH RePORTER →