Modeling the impact of cervical cancer prevention in Zambia

$59,745U01FY2024AINIH

Universitat Bern, Bern

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Abstract

Project summary Cervical cancer is the fourth leading cause of cancer death globally and the leading cause of cancer death in women in 36 countries, including Zambia. The costs of implementing cervical cancer prevention programs are high. Thus, Zambian health policymakers need to identify the optimal cervical cancer prevention strategies for their setting. Mathematical models can help generate such evidence. However, few model-based evaluations have considered the impact of HIV on cervical carcinogenesis, and no such models are available for Zambia. The proposed project aims to assist policymakers in Zambia in deciding on the optimal cervical cancer prevention policy. Specifically, it aims (i) to adapt the openly available HPVsim model to Zambia using robust estimates obtained through the analysis of Zambia-specific HPV and cervical cancer- related databases, (ii) to enhance the HPVsim model by adding more detailed information on cervical cancer stage at diagnosis, and (iii) to generate evidence on the (cost-)effectiveness of cervical cancer prevention policies using the enhanced HPVsim model.

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