Administrative Supplement - Desinging peptide macrocycles to selectively inhibit BET proteins: Martinez Noa, Yisel

University Of Florida, Gainesville FL

Investigators

Linked publications, trials & patents

Abstract

BET proteins are involved in mul3ple diseases associated with the misregula3on of immune response genes. Through the parent grant we are characterizing the ET domain for its poten3al as a drug target and iden3fying the origin of selec3vity across homologous ET domains. Within this supplement we take a further step and propose the design and characteriza3on of pep3de macrocycles as poten3al drugs using an array of computa3onal chemistry tools, which we will later characterize with our experimental collaborators.