Mechanisms of hemoglobin utilization by Mycobacterium tuberculosis
$125,187P20FY2024GMNIH
University Of Oklahoma Hlth Sciences Ctr, Oklahoma City OK
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Abstract
Mycobacterium tuberculosis (Mtb), a lung pathogen, is dependent on iron acquisition to successfully colonize the human host. Mtb secretes siderophores to acquire iron from host transferrin, ferritin and lactoferrin, but the siderophores cannot access iron in heme (Hm) or hemoglobin (Hb), which store greater than 75% of host iron. Recently, it was shown that the necrotic centers of TB granulomas (infected macrophages) contain high concentrations of host Hm- and Hb-sequestering proteins to limits access of Mtb to Hm iron.
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