Retinal Ganglion Cell Replacement in Optic Neuropathies

Stanford University, Stanford CA

Investigators

Linked publications, trials & patents

Abstract

PROJESCUTMMARY Glaucioasmlaeadcianugsoefbslindanneadslsownigtohthoeprtniecuropaitcshiaersactbeyrize thleososfretgiannagllcieol(nlRsGCIsn)c.reiansterdaporceuslsa(urIrOmePa)nagemietsnhcteurrent standoafcradrfeogrlaucpoamtaiebnuftasit,losstotphierrevelrossoisfRbGlCeasnpdrogrevsissiuvael dysfunVcitsiirooenns.totrhartoiRuoGgnChreplactehmeernoatnpoeyft,hNeElA'usdacGioauplsrsogram, coubledapotenstoilaultaincodonn,sidperoagbrlheasbsseemnadienundersttahnmedoilnegcular signtahlrasetguRlGaCtsepeciffircoahmtuimoasntecmelalswse,lalsinRGCtransapnlidannttegirnatio rodeHnotwse.vwehre,cnonsidterrainnsgolflaatbiornaadtvoarnytcoheusmatnestriondgem,notdealrse limibtycerditdiicffaelreinnrceetspihnyaslioalnopdgryo,of-ofi-ncoonn-cheupmrtainmawtoeugslrdeatly increcaosnefidaennadciiedntherapdeeuvteilcopbmeefnomtroevitnohgumatnestTihnutgsh.eirsae considneereafdboalrteractnaobnl-ehupmrainmmaotdeeHle.rweewielsltabalsiqsuhimrornekley-indu glaucmoomdaealntdhpearamettosetrushduymasntecmell-dReGrCiinvteedgarnapdtoitoennvtiisailon restorianrteitoainnnvdaissuyasltcelmotsoetrhoosfheumaTnh.routgh5hi-syeparropowsewailll achicervietmiiclaelstionncelsuv,dailnigdtahtmeionngkgelyaucmoomdaeslt,udkyeisyntgrucatnudral functmieoansaulurseisinngnovnaetwivmeodtahlsaihttoiueblsepdortbaebtlweemeonkaenyhdumans, andemonsttrhametoidnegalb'istlomiotvyaecroisnsstitAulotlftihowinissbl.elaccompliintshhseeedtting ofstudyRiGCntgransdpilffaenrte:nmtiigartailtooincio,anlt,egarnasdtyinoanfposremagtrioowdnto,hwtnhe optniecrvaen,tdargettodiinsbgtraalniunclweiit,hgotaohlfveisrieosntoration.