Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American Populations

Chapman University, Orange CA

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Abstract

The aim of the proposed administrative supplement is to conduct enhanced computerized tomography (CT) of the brain, mouth/jaw, neck, abdominal aorta, spine, and pelvis by making use of a newly available CT scanner in Bolivia. The new Canon Aquilion Prime SP CT scanner was installed in 2023, and this scanner offers both greater resolution and lower radiation exposure than the original scanner that was previously available. The new scanner will enhance the study of brain aging (Aim 1 of the parent award) with greater differentiation of grey and white matter, regional brain volumes, and intracranial calcifications. Supplemental funds are requested for the increased costs of the enhanced scanning capabilities and to increase imaging coverage to include the abdomen and pelvis, extending the measurement of arteriosclerosis to other arterial beds.