Albino Deletion Complex and Early Mouse Development

Univ Of North Carolina Chapel Hill, Chapel Hill NC

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Abstract

Chromatin remodeling complexes are essential for maintaining chromatin structure and transcriptional regulation. The precise control of remodeling complex recruitment and assembly on targeted chromatin loci is crucial for epigenetic memory. Various factors Include activation or repression of transcription, chromatin- binding proteins, and histone modifications. These mechanisms are essential for mammalian spermatogenesis, where epigenetic changes occur as germ cells transition from precursor to sperm. Successful execution of the meiotic program necessitates the induction and repair of DNA double-strand breaks to enable recombination between homologous chromosomes. Several factors involved in repairing DNA damage in somatic cells are also involved in male meiosis. Chromatin-remodeling complexes, in addition to regulating gene regulation, also play a role in DNA repair, regulation of gene expression, and meiotic sex chromosome inactivation. Current experiments investigate how SWI/SNF and INO80 remodeling complex subunits regulate epigenetic memory during spermatogenesis.