GH CONCENTRATIONS FOLLOWING TREATMENT FOR ACUTE LEUKEMIA
$0M01FY2002RRNIH
Weill Medical College Of Cornell Univ, New York NY
Investigators
Linked publications & trials
Paper 22292110Paper 20977343Paper 19906219Paper 19391080Paper 19017985Paper 18097152Paper 17316097Paper 17079285Paper 16763388Paper 16339698Paper 15526720Paper 15270860Paper 14962217Paper 14703595Paper 14625263Paper 14581545Paper 12654942Paper 12525204Paper 12468338Paper 12442030Paper 12393516Paper 12027270Paper 11967296Paper 11880731Paper 11821496Paper 11781358Paper 11605171Paper 11391167Paper 11335777Paper 11335753Paper 11170984Paper 11135346Paper 11085758Paper 11075607Paper 10912545Paper 10880061Paper 10807191Paper 10783035
Abstract
We will test the hypothesis that the therapies currently employed to treat childhood leukemias and lymphomas (systemic/intrathecal chemotherapy and lwo-dose, 1800cGy, cranial radiation) cause damage to the neuroregulatory centers int he brain responsible for the sex steroid mediated increase in growth hormone production. As a consequence, these individuals produce normal amounts of GH in the prepubertal years but fail to demonstrate the expected increase in GH concentration in response to sex steroids (both endogenous and exogenous).
View original record on NIH RePORTER →